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With the simultaneous use of CYP3A4 inhibitors ketoconazole, erythromycin, help essays, cimetidinehelp essays, a decrease in the clearance of sildenafil was noted. Sildenafil has no effect on the pharmacokinetic parameters of saquinavir.
Stronger inhibitors of the CYP3A4 isoenzyme, such as ketoconazole and itraconazole, may cause more pronounced changes in the pharmacokinetics of sildenafil. This is consistent with the effect of ritonavir on a wide range of cytochrome P substrates. Sildenafil does not affect the pharmacokinetics of ritonavir.
Given these findings, concomitant use of ritonavir and sildenafil is not recommended. In any case, the maximum dose of sildenafil should under no circumstances exceed 25 mg in 48 hours. custom research help essays writing. RICH TRADITION buying essays The pressure of other help essays on the metabolism of sildenafil.
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